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Infectious Diseases

Clinical Research in Times of Ebola… and other Epidemics

As the news trickles in about the raging cholera outbreak in Yemen, and an emerging outbreak is being dealt with urgently in North-Eastern Nigeria, we are more frequently being confronted with the uncomfortable question of leveraging these situations to conduct clinical research activities. The National Academies of Science, Engineering and Medicine (NASEM) have come out… Keep Reading

#VisualAbstracts: Humans, Bats, Trees, Culture and Nipah Virus Transmission

A recent publication in the CDC’s Emerging Infectious Diseases journal talks about the factors related to the emergence of zoonotic infections. They have studied Nipah virus infections in man. This is another effort to bring visual abstracts for infectious disease publications of interest to me. The abstract of the paper: Preventing emergence of new zoonotic… Keep Reading

Comparing the Rotavirus Vaccines in India

Comparisons of different rotavirus vaccines are difficult to make with a lot of precision because of the differing populations, protocols, attack rates, and study procedures which have been employed to assess the efficacy of the vaccines. Given the rather recent deployment of the vaccines, there are very limited evidence on their effectiveness in the population/community-setting.… Keep Reading

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Turning to the "Infected Jelly" to Treat Ebola

The NEJM has come out with a very interesting paper: Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The explosive outbreak of Ebola Virus Disease in West Africa last year had hijacked the headlines and media space in a big way. Multiple solutions were touted, including the vaccine trial STRIVE. Few articles, however, looked… Keep Reading

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If Carbapenems Go, Can Colistin be Far Behind?

I wrote about the disaster-in-the-making discovery of transmissible resistance to colistin, a last resort antibiotic, when the Lancet Infectious Diseases published a paper based on data coming out from surveillance in China. At that point of time, the isolation of the transmissible gene providing resistance (mcr1 gene) gained a lot of attention. Maryn McKenna’s blog post went… Keep Reading

Infectious Diseases

Dengue Vaccines: A Quick Overview

The rising tide of dengue has slowed down in Delhi as the temperatures have started to dip. In the mean time, Mexico has created a ripple by approving the use of Dengvaxia, a tetravalent vaccine against dengue a few days ago. So, I was drawing up a summary of the different vaccines in play, and… Keep Reading

The Apocalypse is HERE: Transmissible Resistance to Last Resort Antibiotic (Colistin)

Polymyxins are a group of bacterial origin cyclic polypeptides with antibacterial properties. It was isolated by a Japanese researcher in 1949 from a jar of fermenting bacteria. Colistin, also known as Polymyxin E, which is produced by the bacteria Paenibacillus polymyxa var. colistinus, is a polypeptide antibiotic, which is effective against almost all gram-negative bacilli. Owing to its nephrotoxocity and… Keep Reading

Infectious Diseases

Anthelminthic Drug Donation in the Epoch of Drug Resistance

The Journal of Global Antimicrobial Resistance has published an interesting review article discussing the impact of scale up of drug donations to control neglected helminthiasis in the developing countries through aid-assisted preventive chemotherapy of vulnerable populations. The highlights of the article include: Scale-up in drug donations for control of Neglected Tropical Diseases subject to Preventive… Keep Reading

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