Category archive

Infectious Diseases

#VisualAbstracts: Humans, Bats, Trees, Culture and Nipah Virus Transmission

A recent publication in the CDC’s Emerging Infectious Diseases journal talks about the factors related to the emergence of zoonotic infections. They have studied Nipah virus infections in man. This is another effort to bring visual abstracts for infectious disease publications of interest to me. The abstract of the paper: Preventing emergence of new zoonotic… Keep Reading

Comparing the Rotavirus Vaccines in India

Comparisons of different rotavirus vaccines are difficult to make with a lot of precision because of the differing populations, protocols, attack rates, and study procedures which have been employed to assess the efficacy of the vaccines. Given the rather recent deployment of the vaccines, there are very limited evidence on their effectiveness in the population/community-setting.… Keep Reading

Infectious Diseases/Medcetera

Aphorisms #2: Antimicrobial Resistance

The prescient words of Alexander Fleming, who was awarded the Nobel Prize in Medicine or Physiology in 1945 for his seredipitous discovery of the antibiotic, Penicillin, are worth a mention when it comes to discussing the wise aphorisms around antimicrobial resistance. In an interview given to The New York Times in 1945, he notes that:… Keep Reading

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Infectious Diseases/Medcetera

Aphorisms #1: Antimicrobial Resistance

I am working on a document outlining strategies for monitoring and surveillance of antimicrobial resistance (hence the recent plethora of posts on the topic!) and sometimes, these documents spout some beautifully poetic paragraphs amidst pages and pages of policy jargon! So I thought of blogging them as and when I come across them! From  Shaban… Keep Reading

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Turning to the "Infected Jelly" to Treat Ebola

The NEJM has come out with a very interesting paper: Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The explosive outbreak of Ebola Virus Disease in West Africa last year had hijacked the headlines and media space in a big way. Multiple solutions were touted, including the vaccine trial STRIVE. Few articles, however, looked… Keep Reading

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If Carbapenems Go, Can Colistin be Far Behind?

I wrote about the disaster-in-the-making discovery of transmissible resistance to colistin, a last resort antibiotic, when the Lancet Infectious Diseases published a paper based on data coming out from surveillance in China. At that point of time, the isolation of the transmissible gene providing resistance (mcr1 gene) gained a lot of attention. Maryn McKenna’s blog post went… Keep Reading

Infectious Diseases

Dengue Vaccines: A Quick Overview

The rising tide of dengue has slowed down in Delhi as the temperatures have started to dip. In the mean time, Mexico has created a ripple by approving the use of Dengvaxia, a tetravalent vaccine against dengue a few days ago. So, I was drawing up a summary of the different vaccines in play, and… Keep Reading

The Apocalypse is HERE: Transmissible Resistance to Last Resort Antibiotic (Colistin)

Polymyxins are a group of bacterial origin cyclic polypeptides with antibacterial properties. It was isolated by a Japanese researcher in 1949 from a jar of fermenting bacteria. Colistin, also known as Polymyxin E, which is produced by the bacteria Paenibacillus polymyxa var. colistinus, is a polypeptide antibiotic, which is effective against almost all gram-negative bacilli. Owing to its nephrotoxocity and… Keep Reading

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